COVID-19: JN.1 sub-variant ine yakanyanya kutapurirana uye kugona kudzivirira immune 

Spike mutation (S: L455S) chiratidzo chekuchinja kweJN.1 sub-variant iyo inosimudzira zvakanyanya simba rayo rekudzivirira kudzivirira kwezvirwere zvichiita kuti ikwanise kunzvenga masoja ekudzivirira chirwere cheKirasi 1. Chidzidzo chinotsigira kushandiswa kweakagadziridzwa COVID-19 vaccines ane spike protein kuti arambe achidzivirira veruzhinji.  

Kuwedzera Covid-19 nyaya dzacho dzakashumwa munzvimbo dzakawanda dzenyika. A itsva sub-variant JN.1 (BA.2.86.1.1) iyo yakashanduka nekukurumidza kubva kuBA.2.86 musiyano munguva pfupi yapfuura yave ichikonzera kunetseka.  

JN.1 (BA.2.86.1.1) sub-variant ine imwe spike mutation (S: L455S) zvichienzaniswa neinotangira BA.2.86. Uku ndiko kuchinjika kweJN.1 kunosimudzira zvakanyanya kugona kwayo kunzvenga masoja emuviri zvichiita kuti ikwanise kunzvenga masoja ekudzivirira chirwere cheKirasi 1. JN.1 inotakurawo shanduko nhatu mumapuroteni asiri eS. Pakazere, JN.1 yakawedzera transmissibility uye immune immune kupukunyuka^1,2.  

Majekiseni eCCIDID-19 auya kure kure kubva padenda uye akagadziridzwa maererano neprotein ye spike kusangana nematambudziko akaunzwa nevachangobva kubuda akasiyana.  

Ongororo ichangoburwa inoratidza kuti yakagadziridzwa monovalent mushonga we mRNA (XBB.1.5 MV) inoshanda mukusimudzira serum virus-neutralization masoja ekudzivirira chirwere zvakanyanya kupikisa akawanda madiki-siyana anosanganisira anopokana neJN.1. Chidzidzo ichi chinotsigira kushandiswa kwakagadziridzwa COVID-19 vaccine ine spike protein kuti iwedzere kuchengetedza veruzhinji³.  

Kana JN.1 sub-variant ichipa njodzi yakawedzera kuhutano hweveruzhinji maererano nemamwe akasiyana ari kutenderera parizvino, CDC inoti hapana humbowo.⁴.  

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References:  

1. Yang S., and said 2023. Kukurumidza kushanduka kweSARS-CoV-2 BA.2.86 kusvika kuJN.1 pasi pesimba rinorema rekudzivirira muviri. Preprint bioRxiv. Yakatumirwa Mbudzi 17, 2023. DOI: https://doi.org/10.1101/2023.11.13.566860  
2. Kaku Y., and said 2023. Virological maitiro eSARS-CoV-2 JN.1 musiyano. Preprint bioRxiv. Yakatumirwa Zvita 09, 2023. DOI: https://doi.org/10.1101/2023.12.08.570782  
3. Wang Q. and said 2023. XBB.1.5 monovalent mRNA vaccine booster inoita kuti masoja ekudzivirira ekudzivirira akasimba apedzisire ari kubuda eSARS-CoV-2 akasiyana. Preprint bioRxiv. Yakatumirwa Zvita 06, 2023. DOI: https://doi.org/10.1101/2023.11.26.568730  
4. Muzinda weKuDzivirirwa kweZvirwere. Kugadziridza paSARS-CoV-2 Variant JN.1 Kuteverwa neCDC. Inowanikwa pa https://www.cdc.gov/respiratory-viruses/whats-new/SARS-CoV-2-variant-JN.1.html   

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