Interferon-β Yekurapa kweCCIDID-19: Subcutaneous Administration inonyanya Kushanda

Mhedzisiro kubva muyedzo yechikamu che2 inotsigira maonero ekuti subcutaneous manejimendi yeIFN- β yekurapa COVID-19 inowedzera kukurumidza kupora uye inoderedza kufa..

Mamiriro ezvinhu anoshamisa akaunzwa nedenda reCCIDID-19 akakurudzira kuongorora nzira dzakasiyana siyana dzekurapa nyaya dzakakomba dzeCCIDID-19. Mishonga mitsva yakawanda iri kuyedza uye mishonga iripo iri kushandiswa patsva. Corticosteroids zvakatowanikwa zvichibatsira. Interferon therapy yatove kushandiswa kune hutachiona hwehutachiona senge hepatitis. IFN inogona kushandiswa kurwisa SARS CoV-2 muCOVID-19?  

Mune preclinical miedzo yapfuura, IFN yanga yaratidza kuve inoshanda kurwisa SARS CoV uye MERS mavhairasi. Muna Chikunguru 2020, kutonga kweInterferon-β kuburikidza nebulisation (kureva pulmonary inhalation) nzira yakanzi yakaratidza mhedzisiro inovimbisa mukurapa kwakanyanya COVID-19 kesi zvichibva pane data kubva muchikamu chechipiri chekiriniki kuyedzwa. ^1,2.  

Ikozvino, chirevo chazvino chakavakirwa padhata kubva kuchikamu chechipiri chekuyedza kiriniki chakaitwa pavarwere zana negumi nevaviri vane COVID-2 vari muchipatara kuPitié-Salpêtrière muParis, France inoratidza kuti kutonga kweIFN- β kuburikidza ne subcutaneous nzira kunowedzera kupora uye kuderedza kufa muCOVID-112. nyaya ³.   

Interferon (IFN) mapuroteni anovanzwa nemasero anogashira achipindura kutapukira kwehutachiwana kuratidza mamwe masero ekuvapo kwehutachiona. Iyo yakawedzera kuzvimba mhinduro mune vamwe varwere veCCIDID-19 inowanikwa iine hukama nekukanganisa IFN-1 mhinduro uye blockade. IFN-β secretion. Inoshandiswa mu China kurapa viral pneumonia nekuda kweSARS CoV asi kushandiswa kwayo hakuna kuomeswa ⁴.  

Chikamu chechitatu chekuyedzwa kwekiriniki yekushandiswa kweInterferons (IFN) mukurapa varwere vakakomba COVID-3 chiri kuenderera mberi. Mvumo ichaenderana nekuti zvigumisiro zvekupedzisira zviri mukati mehutano hunogamuchirwa hunotsanangurwa nevatongi.   

***

Sources:   

1. NHS 2020. Nhau- Mushonga wakafemerwa unodzivirira varwere veCCIDID-19 kuwedzera mukuyedzwa kweSouthampton. Yakatumirwa musi wa20 Chikunguru 2020. Inowanikwa online pa https://www.uhs.nhs.uk/ClinicalResearchinSouthampton/Research/News-and-updates/Articles/Inhaled-drug-prevents-COVID-19-patients-getting-worse-in-Southampton-trial.aspx Yakasvika musi wa12 Kukadzi 2021.  

2. Monk PD., Marsden RJ., Tear VJ., et al., 2020. Kuchengeteka uye kushanda kweiyo inhaled nebulised interferon beta-1a (SNG001) kurapwa kweSARS-CoV-2 hutachiona: a randomised, double-blind, placebo- inodzorwa, chikamu 2 kuyedza. Iyo Lancet Respiratory Medicine, Inowanikwa online 12 Mbudzi 2020. DOI: https://doi.org/10.1016/S2213-2600(20)30511-7 

3. Dorgham K., Neumann AU., et al 2021. Tichifunga nezvemunhu wega Interferon-β kurapa kweCOVID-19. Antimicrobial Agents Chemotherapy. Yakatumirwa Pamhepo 8 Kukadzi 2021. DOI: https://doi.org/10.1128/AAC.00065-21  

4. Mary A., Hénaut L., Macq PY., et al 2020. Chikonzero cheCOVID-19 Kurapwa neNebulized Interferon-β-1b-Literature Ongororo uye Chiitiko Chako Chekutanga. Frontiers muPharmacology., 30 Mbudzi 2020. DOI:https://doi.org/10.3389/fphar.2020.592543.  

***