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RNA Tekinoroji: kubva kuVaccines kurwisa COVID-19 kuenda Kurapwa kwechirwere cheCharcot-Marie-Tooth

RNA tekinoroji yakaratidza kukosha kwayo munguva pfupi yapfuura mukuvandudza mRNA vaccines BNT162b2 (yePfizer/BioNTech) uye mRNA-1273 (yeModerna) kurwisa COVID-19. Zvichienderana nekudzikisira iyo coding RNA mumuenzaniso wemhuka, masayendisiti echiFrench akataura zano rakasimba uye humbowo hwepfungwa yekurapwa kweCharcot-Marie-Tooth. chirwere, chirwere chinowanzogara nhaka chetsinga chinokonzera kupera simba kwemakumbo nemaoko.  

Muna 1990, vatsvakurudzi vakaratidza kekutanga jekiseni rakananga re mRNA mumhasuru yemakonzo inotungamira kukuratidzira kweprotein yakavharidzirwa mumaseru emhasuru. Izvi zvakavhura mukana wekuvandudzwa kwegene-based vaccines uye therapeutics.  

Mamiriro asina kuratidzwa akaunzwa neCCIDID-19 denda, akatungamira mubudiriro uye mvumo yekushandisa emergency (EUA) yemRNA-yakavakirwa. vaccines BNT162b2 (ye Pfizer/BioNTech) uye mRNA-1273 (ye Dzazvino) kurwisa COVID-19. Vaviri ava vaccines zvichibva paRNA tekinoroji yakaita basa rakakosha mukudzivirira vanhu kubva kuzviratidzo zvakakomba zveCOVID-19.  

Kubudirira kweRNA tekinoroji yakavakirwa COVID-19 vaccines yaionekwa senhanho musainzi nemushonga sezvo yakaratidza kukodzera kwehunyanzvi hwekurapa hwepamusoro uhwo nharaunda yesainzi neindasitiri yemishonga yave ichitsvaga kweanoda kusvika makumi matatu emakore. Yakapa kurudziro inodiwa pakuongorora kweRNA tekinoroji-yakavakirwa therapeutics.  

Chirwere cheCharcot-Marie Tooth ndicho chinowanzogara nhaka chetsinga chirwere. Mitsipa yeperipheral inobatwa izvo zvinotungamirira mukuoma mitezo kwemakumbo nemaoko. Chirwere ichi chinokonzereswa nekuda kwekuwedzeredza kweprotein chaiyo inonzi PMP22. Kusvika pari zvino hapana mushonga wekurwisa chirwere ichi.  

Masayendisiti epaCNRS, INSERM, AP-HP uye Paris-Saclay neParis mayunivhesiti muFrance achangobva kuzivisa kuvandudzwa kwekurapa kunobva mukudzikisira uye kudzikisira coding RNA yePMP22 protein. Kune izvi, vakashandisa imwe siRNA (diki inopindira RNA) molecule inokanganisa iyo RNA kukodha yePMP22 protein.  

Vatsvakurudzi vakawana kuti jekiseni re siRNA (duku rinopindira RNA) mumhando yemakonzo echirwere yakaderedza huwandu hwePMP22 protein kusvika kune yakajairwa uye yakadzoreredzwa locomotion uye simba remhasuru. Zvidzidzo zvehistological zvakaratidza kuvandudzwa uye kudzoreredzwa kwebasa remyelin sheaths. Mhedzisiro yakanaka yakagara kwemavhiki matatu, uye jekiseni idzva reSiRNA rakakonzera kupora kwakazara kwekushanda.  

ichi kudzidza yakakosha nekuti inopa zano rakasimba rekurapwa kwenhaka peripheral neuropathies. Inopa iyo humbowo hwepfungwa yemushonga mutsva chaiwo wakavakirwa pakushandisa tekinoroji yeRNA kugadzirisa yakawandisa gene kutaura kuburikidza nekushandiswa kwekukanganisa RNA.  

Nekudaro, kurapwa chaiko kwemurwere kuchiri kure kusvika zvikamu zvinotevedzana zvekuedzwa kwekiriniki zvichipa chengetedzo inogutsa uye mhedzisiro yekubudirira kune vanodzora.  

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Sources:  

  1. Prasad U., 2020. COVID-19 mRNA Vaccine: Nhanho muSainzi uye Mutambo Wekuchinja Mushonga. Scientific European. Yakatumirwa 29 Zvita 2020. Inowanikwa pa https://www.scientificeuropean.co.uk/covid-19/covid-19-mrna-vaccine-a-milestone-in-science-and-a-game-changer-in-medicine/  
  1. Press Release - Inserm Press Room - Charcot-Marie Tooth chirwere: A 100% French RNA-based therapeutic innovation. Link: https://presse.inserm.fr/en/charcot-marie-tooth-disease-a-100-french-rna-based-therapeutic-innovation/42356/  
  1. Boutary, S., Caillaud, M., El Madani, M. et al. Squalenoyl siRNA PMP22 nanoparticles inoshanda mukurapa mhando dzembeva dzeCharcot-Marie-Tooth chirwere cherudzi 1 A. Commun Biol 4, 317 (2021). https://doi.org/10.1038/s42003-021-01839-2 

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Chikwata cheSCIEU
Chikwata cheSCIEUhttps://www.scientificeuropean.co.uk
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