Masayendisiti akagadzira 3D bioprinting chikuva chinounganidza kushanda munhu neural tishu. Maseru ekutanga ari mumatishu akadhindwa anokura kuita neural circuits uye anoita hukama hunoshanda nemamwe ma neuron nokudaro achitevedzera zvakasikwa. ubongo tishu. Uku kufambira mberi kwakakosha mune neural tissue engineering uye mu 3D bioprinting tekinoroji. Mabioprinted neural tissues akadaro anogona kushandiswa mukuenzanisira munhu zvirwere (zvakadai seAlzheimer's, Parkinson's etc.) zvinokonzerwa nekuda kwekukanganiswa kweneural network. Chero kuferefetwa kwechirwere chehuropi kunoda kunzwisisa kuti sei munhu Neural network inoshanda.
3D bioprinting inzira yekuwedzera apo yakakodzera yakasikwa kana yekugadzira biomaterial (bioink) inosanganiswa nemasero mapenyu uye yakadhindwa, layer-by-layer, munyama yechisikigo-se-matatu-dimensional zvimiro. Masero anokura mubioink uye zvimiro zvinokura kutevedzera matishu chaiwo kana nhengo. Iyi tekinoroji yakawana maapplication mukati regenerative mushonga we bioprinting yemasero, matishu uye nhengo uye mukutsvaga semuenzaniso wekudzidza munhu muviri ezvokunambira kunze kwomuviri waamai, kunyanya munhu nervous system.
Kudzidza kwe munhu nervous system inotarisana nekugumira nekuda kwekushaikwa kwekutanga samples. Mienzaniso yemhuka inobatsira asi inotambura kubva kune mhando-yakananga misiyano saka zvakakosha zve ezvokunambira kunze kwomuviri waamai mienzaniso ye munhu nervous system kuongorora kuti sei munhu neural network inoshanda yakananga kutsvaga marapirwo ezvirwere zvinokonzerwa nekukanganiswa kweneural network.
munhu neural tissues akadhindwa 3D munguva yakapfuura achishandisa stem maseru asi aya akashaya neural network formation. Matishu akadhindwa akange asina kuratidza kuve akagadzira hukama pakati pemasero nekuda kwezvikonzero zvakati. Kukanganisa uku kwakakurirwa zvino.
Muongororo yakaitwa munguva pfupi yapfuura, vatsvakurudzi yakasarudza fibrin hydrogel (inosanganisira fibrinogen uye thrombin) seyakanyanya bioink uye yakaronga kudhinda chimiro chakaiswa mukati umo maseru ekutanga anogona kukura uye kugadzira masinapses mukati nepakati pematanho, asi akachinja nzira iyo maraya anoturikidzwa panguva yekudhinda. Panzvimbo pechinyakare nzira yekuturika matinji, ivo vakasarudza kudhinda matinji padivi peimwe yakachinjika. Sezviri pachena, izvi zvakaita musiyano. Yavo 3D bioprinting chikuva chakawanikwa kuungana chinoshanda munhu neural tissue. Kuvandudza pamusoro pemamwe mapuratifomu aripo, iyo munhu Neural tishu yakadhindwa nepuratifomu iyi yakagadzira neural network uye inoshanda yekubatanidza nemamwe maneurons uye glial masero mukati uye pakati pematanho. Iyi ndiyo kesi yekutanga yakadai uye inhanho yakakosha kumberi mune neural tissue engineering. Murabhoritari synthesis yetsinga tishu inotevedzera uropi mukushanda inonzwika inonakidza. Kufambira mberi uku kunozobatsira vaongorori mukuenzanisira munhu Zvirwere zvehuropi zvakakonzerwa nekuda kwekukanganiswa neural network kuti unzwisise zviri nani magadzirirwo ekutsvaga kurapwa.
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References:
- Cadena M., and said 2020. 3D Bioprinting yeNeural Tissues. Advanced Healthcare Materials Volume 10, Issue 15 2001600. DOI: https://doi.org/10.1002/adhm.202001600
- Yan Y., and said 2024. 3D bioprinting ye munhu neural tissues ine functional connectivity. Sero Stem Cell Technology| Vhoriyamu 31, Nyaya 2, P260-274.E7, Kukadzi 01, 2024. DOI: https://doi.org/10.1016/j.stem.2023.12.009
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